Knowledge about the cross-regulation between pathways is mostly limited to the hepatic availability/removal of substrates and inhibitors. Additionally, abnormalities in homocysteine metabolism link nutrition and hearing loss. Several transsulfuration proteins regulate gene expression, suggesting moonlighting activities. In contrast to the classical view, a nuclear branch of the pathway, potentiated under oxidative stress, is emerging. Major hepatic diseases, rare diseases and sensorineural disorders, among others that concur with oxidative stress, present impaired transsulfuration. Transsulfuration presents multiple interconnections with epigenetics, ATP and glutathione synthesis, polyol and pentose phosphate pathways and detoxification that rely mostly in the exchange of substrates or products. methionine, vitamins) and is regulated by their availability. This pathway produces S-adenosylmethionine, a key metabolite for cell function, and provides 50% of the cysteine needed for hepatic glutathione synthesis.The route requires the intake of essential nutrients (e.g. Transsulfuration allows conversion of methionine into cysteine using homocysteine as an intermediate.
0 kommentar(er)
